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KMID : 1234420090370010075
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Korean Journal of Microbiololgy and Biotechnology
2009 Volume.37 No. 1 p.75 ~ p.79
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Biosafety of the New Soft Contact Lens Materials in the Fibroblast L-929 Cell Line
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You Young-Hyun
Nam Joo-Hyeung
Kim Bieong-Kil
Kim Soon-Bok
Moon Ik-Jae
Kim Jong-Pil
Seu Young-Bae
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Abstract
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In this study, we polymerized new materials for soft contact lens using HEMA (2-hydroxyethyl methacrylate) which is the based-monomer of soft contact lens, EGDMA (ethylene glycol dimethacrylate) as cross linkage agent, and the new additives of monoester or di-ester derived from itaconic acid commercially produced by the fermentation of Asp. itaconicus. New polymer materials for soft contact lens were synthesized with the mixture of HEMA and mono- or diester at different ratios and presented to a good water content and oxygen transmissibility (Dk/L) values. In case of polymerization with HEMA and mono-ester (15%), the water content and oxygen transmissibility of contact lens were found to be good values at 57.6% and 28.5 Dk respectively. The mixture of HEMA and mono-ester is more excellent than HEMA/di-ester in the water content and oxygen transmissibility. The toxicity of new contact lens materials were confirmed in the fibroblast L-929 cell line using a agar overlay test and a growth inhibition test with the extract solution of contact lens.
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KEYWORD
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Itaconic acid, soft contact lens, fibroblast L-929, agar overlay test, growth inhibition test
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